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What do we know about the XBB.1.5 Omicron subvariant?

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GENEVA — The Omicron subvariant, XBB.1.5, is causing concern among scientists after its rapid spread in the United States in December.

Here is what we know so far:

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The World Health Organization’s senior epidemiologist Maria Van Kerkhove said XBB.1.5 is the most transmissible Omicron sub-variant that has been detected so far. It spreads rapidly because of the mutations it contains, allowing it to adhere to cells and replicate easily.

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“Our concern is how transmissible it is,” Van Kerkhove said in a briefing with reporters on Wednesday.

XBB and XBB.1.5 were estimated to account for 44.1% of COVID-19 cases in the United States in the week of Dec. 31, up from 25.9% in the previous week, according to data from the U.S. Centers for Disease Control and Prevention. It has also been detected in 28 other countries worldwide, the WHO said.

XBB.1.5 is yet another descendant of Omicron, the most contagious variant of the virus causing COVID-19 that is now globally dominant. It is an offshoot of XBB, first detected in October, which is itself a recombinant of two other Omicron sub-variants.


The WHO said it does not have any data on severity yet, nor does it have a clinical picture on its impact. It said that it saw no indication that its severity had changed but that increased transmissibility is always a concern.

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“We do expect further waves of infection around the world, but that doesn’t have to translate into further waves of death because our countermeasures continue to work,” said Van Kerkhove, referring to vaccines and treatments.

She said the WHO was unable to currently attribute the increase in hospitalizations in the north-eastern United States to the variant given that many other respiratory viruses were also in circulation.

Virologists agree that the emergence of the new subvariant does not mean there is a new crisis in the pandemic. New variants are to be expected as the virus continues to spread.

XBB.1.5 is likely to spread globally, but it remains unclear if it will cause its own wave of infections around the world. Current vaccines continue to protect against severe symptoms, hospitalization and death, the experts say.

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“There is no reason to think that XBB.1.5 is of any more concern than other variants that come and go in the ever-changing landscape of COVID-19 mutants,” said Professor Andrew Pollard, director of the Oxford Vaccine Group.


The WHO’s Technical Advisory Group on Virus Evolution is doing a risk assessment on the subvariant. Van Kerkhove said on Wednesday it hoped to publish that in the next few days.

The WHO said it was closely monitoring any possible changes in the severity of the subvariant with the help of laboratory studies and real world data. (Reporting by Gabrielle Tétrault-Farber and Jennifer Rigby; Editing by Hugh Lawson)



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